The Effect of Hyperbaric Oxygen Therapy on Kidneys in a Rat Model

被引：8
作者：
Berkovitch, Matitiahu [1 ]
Tsadik, Roni [1 ]
Kozer, Eran [1 ]
Abu-Kishk, Ibrahim [1 ]
机构：
[1] Tel Aviv Univ, Sackler Sch Med, Div Pediat, Pediat Intens Care Unit,Assaf HaRofeh Med Ctr, IL-70300 Zerifin, Israel
来源：
SCIENTIFIC WORLD JOURNAL | 2014年
关键词：
ACUTE-RENAL-FAILURE; OXIDATIVE STRESS; CARBON-MONOXIDE; HIGH-PRESSURE; INJURY; DAMAGE; TRIAL;
D O I：
10.1155/2014/105069
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background. Hyperbaric oxygen therapy (HBOT) is used for treating various medical conditions. As far as known yet, HBOT is safe with few major side effects that are easy to avoid using a proper protocol. Renal tubular damage was observed in rats exposed to HBOT in a preliminary study conducted in our institution. Aim. We aimto assess whether HBOT causes renal damage and, if so, whether this is dose dependent. Methods. Thirty-one rats were randomly assigned to three groups. The first group received 10-days HBOT, 100% oxygen at a pressure of 2 atmospheres absolute (2 ATA) for 60 minutes/day, the second received the same treatment for 5 days and the third served as the control. Rat weight, survival, renal function tests, and renal histopathology were analyzed. Results. There were no significant changes in renal function tests in the plasma (cystatin C, urea, creatinine, and electrolytes) between the groups. No significant differences were observed in weight gain or renal histopathological evaluation between all groups. Conclusion. HBOT in this protocol does not cause renal impairment in a rat model, which reinforces the assumption that HBOT is safe in healthy rats, regarding renal function. Further research should be focused on the effect/safety of HBOT on nonhealthy kidneys.
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页数：4
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