Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage

被引：31
作者：
Rejdak, R
Zarnowski, T
Turski, WA
Kocki, T
Zagorski, Z
Zrenner, E
Schuettauf, F
机构：
[1] Univ Tubingen, Hosp Eye, Div Expt Ophthalmol, Dept Pathophysiol Vis & Neuroophthalmol, D-72076 Tubingen, Germany
[2] Med Univ Lublin, Tadeusz Krwawicz Chair Ophthalmol, PL-20079 Lublin, Poland
[3] Med Univ Lublin, Dept Pharmacol, PL-20954 Lublin, Poland
[4] Inst Agr Med, Dept Toxicol, PL-20950 Lublin, Poland
来源：
VISION RESEARCH | 2003年 / 43卷 / 05期
关键词：
KYNA; retinal ganglion cell; NMDA; rat; neuroprotection;
D O I：
10.1016/S0042-6989(02)00682-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：497 / 503
页数：7
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