Convenient supported recyclable material based on dihydrolipoyl-residue for the reduction of disulfide derivatives

被引：4
作者：
Bienvenu, Celine [1 ]
Greiner, Jacques [1 ]
Vierling, Pierre [1 ]
Di Giorgio, Christophe [1 ]
机构：
[1] Univ Nice Sophia Antipolis, CNRS, UMR 6001, Lab Chim Mol Bioact & Aromes,Inst Chim Nice,Fac S, F-06108 Nice 2, France
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 25期
关键词：
Polymer-supported reducing agent; Disulfide; Dihydrolipoic acid; SOLID-PHASE SYNTHESIS; POLYMER; ACID; CONJUGATION; EFFICIENT;
D O I：
10.1016/j.tetlet.2010.04.079
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A quantitative method for the reduction of disulfides, which uses a totally recyclable solid phase supported reducing agent, is reported. D,L-alpha-Lipoic acid was quantitatively condensed on a highly stable 100% PEG Aminomethyl-ChemMatrix (R) resin that can swell in aqueous media as well as in organic solvents. Lipoic residue, subsequently reduced to its dihydrolipoyl form, was utilized as a reducing agent for highly valuable disulfide compounds. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：3309 / 3311
页数：3
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