Prognostic impact of complex karyotype on post-transplant outcomes of myelofibrosis

被引：0

作者：

Okada, Yosuke ^{[1
]}

Takenaka, Katsuto ^{[2
]}

Murata, Makoto ^{[3
]}

Shimazu, Yutaka ^{[4
]}

Tachibana, Takayoshi ^{[5
]}

Ozawa, Yukiyasu ^{[6
]}

Uchida, Naoyuki ^{[7
]}

Wakayama, Toshio ^{[8
]}

Doki, Noriko ^{[9
]}

Sugio, Yasuhiro ^{[10
]}

Tanaka, Masatsugu ^{[5
]}

Masuko, Masayoshi ^{[11
]}

Kobayashi, Hikaru ^{[12
]}

Ino, Kazuko ^{[13
]}

Ishikawa, Jun ^{[14
]}

Nakamae, Hirohisa ^{[15
]}

Matsuoka, Ken-ichi ^{[16
]}

Kanda, Yoshinobu ^{[17
]}

Fukuda, Takahiro ^{[18
]}

Atsuta, Yoshiko ^{[19
,20
]}

Nagamura-Inoue, Tokiko ^{[21
]}

机构：

[1] Jichi Med Univ, Div Hematol, Saitama Med Ctr, Saitama, Japan

[2] Ehime Univ, Dept Hematol, Grad Sch Med Clin Immunol & Infect Dis, Toon, Ehime, Japan

[3] Nagoya Univ, Dept Hematol & Oncol, Grad Sch Med, Nagoya, Aichi, Japan

[4] Kyoto Univ Hosp, Dept Hematol, Kyoto, Japan

[5] Kanagawa Canc Ctr, Dept Hematol, Yokohama, Kanagawa, Japan

[6] Nagoya Daiichi Hosp, Dept Hematol, Japanese Red Cross Aichi Med Ctr, Nagoya, Aichi, Japan

[7] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[8] Shimane Prefectural Cent Hosp, Dept Hematol & Oncol, Izumo, Shimane, Japan

[9] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Hematol Div, Tokyo, Japan

[10] Kitakyushu City Hosp Org, Kitakyushu Municipal Med Ctr, Dept Hematol, Fukuoka, Japan

[11] Niigata Univ, Dept Hematopoiet Cell Therapy, Med & Dent Hosp, Niigata, Japan

[12] Nagano Red Cross Hosp, Dept Hematol, Nagano, Japan

[13] Mie Univ Hosp, Dept Hematol & Oncol, Tsu, Mie, Japan

[14] Osaka Int Canc Inst, Dept Hematol, Osaka, Japan

[15] Osaka City Univ Hosp, Dept Hematol, Osaka, Japan

[16] Okayama Univ Hosp, Dept Hematol & Oncol, Okayama, Japan

[17] Jichi Med Univ, Div Hematol, Shimotsuke, Tochigi, Japan

[18] Natl Canc Ctr, Dept Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[19] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[20] Aichi Med Univ, Dept Registry Sci Transplant & Cellular Therapy, Sch Med, Nagoya, Aichi, Japan

[21] Univ Tokyo, Inst Med Sci, Dept Cell Proc & Transfus, Dept Lab Med, Tokyo, Japan

来源：

HEMATOLOGICAL ONCOLOGY | 2022年 / 40卷 / 05期

关键词：

complex karyotype; hematopoietic cell transplantation; myelofibrosis; ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; CYTOGENETIC-RISK CATEGORIZATION; INTERNATIONAL WORKING GROUP; MONOSOMAL KARYOTYPE; SCORING SYSTEM; TP53; GENE; SURVIVAL; MUTATIONS; ABNORMALITIES;

D O I：

10.1002/hon.3058

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal abnormalities in the role of prognostic factor for transplant patients with myelofibrosis (MF) are not fully investigated. Regarding complex karyotype (CK), we retrospectively analyzed 241 patients with primary and secondary MF who received a first allogeneic hematopoietic cell transplantation (HCT). Based on an unfavorable karyotype in the Dynamic International Prognostic Scoring System, we compared the outcomes in 3 groups: favorable karyotype, unfavorable karyotype including CK (unfavorable-CK(+)), and unfavorable karyotype not including CK (unfavorable-CK(-)). Overall survival was significantly shorter in the unfavorable-CK(+) group (hazard ratio (HR) 2.49, 95% CI: 1.46-4.24, P < 0.001), whereas there was no difference between the unfavorable-CK(-) group and the favorable group (HR 0.57, 95% CI: 0.20-1.59, P = 0.28). In addition, a significantly higher proportion of patients in the unfavorable-CK(+) group did not achieve complete remission after HCT (P = 0.007). The cumulative incidence of disease progression was significantly higher in the unfavorable-CK(+) group (HR 2.5, 95% CI 1.6-3.92, P < 0.001), whereas that in the unfavorable-CK(-) group was comparable to that in the favorable group (HR 0.49, 95% CI 0.12-1.94, P = 0.31). Further investigations will be needed to clarify the impact of CK on transplant outcomes in MF.

引用

页码：1076 / 1085

页数：10

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