Levonorgestrel-releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma

Background. Primary treatment of endometrial cancer with progestogens is reserved for adjuvant or palliative treatment, although with unproven efficacy. Case. We present a case of early endometrial cancer where a combination of oral progestogens and levonorgestrel releasing intrauterine system (Mirena@) was used as a primary treatment, as the standard surgical treatment was deemed to carry an unacceptable mortality risk. Conclusion. Our treatment has resulted in reversion of the cancerous endometrial histological changes. This is encouraging, but obviously more cases and lengthier follow-up time are required in order to obtain more valid conclusions. (C) 2004 Elsevier Inc. All rights reserved.