Methionine cycle in nonalcoholic fatty liver disease and its potential applications

被引：16

作者：

Wang, Haoyu ^{[1
,2
]}

Wu, Yanwei ^{[2
]}

Tang, Wei ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China

来源：

BIOCHEMICAL PHARMACOLOGY | 2022年 / 200卷

关键词：

Methionine Cycle; NAFLD; CYSTATHIONINE BETA-SYNTHASE; HOMOCYSTEINE S-METHYLTRANSFERASE; GLYCINE-N-METHYLTRANSFERASE; AMINO-ACID-METABOLISM; PLASMA HOMOCYSTEINE; OXIDATIVE STRESS; HYDROGEN-SULFIDE; DNA METHYLATION; HEPATIC STEATOSIS; GENE-EXPRESSION;

D O I：

10.1016/j.bcp.2022.115033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis and treatment of NAFLD. Methionine metabolic cycle, which is critical for the maintaining of cellular methylation and redox state, is involved in the pathophysiology of NAFLD. However, the molecular basis and mechanism of methionine metabolism in NAFLD are not completely understood. Here, we mainly focus on specific enzymes that participates in methionine cycle, to reveal their interconnections with NAFLD, in order to recognize the pathogenesis of NAFLD from a new angle and at the same time, explore the clinical characteristics and therapeutic strategies.

引用

页数：17

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