Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans

被引：55

作者：

Kim, Hyungsuk ^{[1
]}

Dionne, Raymond A. ^{[1
]}

机构：

[1] NINR, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR PAIN | 2007年 / 3卷

关键词：

D O I：

10.1186/1744-8069-3-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objectives: To assess the effect of variations in GTP cyclohydrolase gene (GCHI) on pain sensitivity in humans. Methods: Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers. Among this cohort, the clinical pain responses of 221 subjects after the surgical removal of impacted third molars were evaluated. Genotyping was done for 38 single nucleotide polymorphisms (SNPs) whose heterozygosity > 0.2 in GCHI. Influence of the genetic variations including SNPs and haplotypes on pain sensitivity were analyzed. Results: Minor allele frequencies and linkage disequilibrium show significant differences in European Americans, African Americans, Hispanic Americans and Asian Americans. Association analyses in European Americans do not replicate the previously reported important influence of GCHI variations on pain sensitivity. Conclusion: Considering population stratification, previously reported associations between GCH1 genetic variations and pain sensitivity appear weak or negligible in this well characterized model of pain.

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页数：9

相关论文

共 16 条

[1]

[Anonymous], HUMAN MOL GENETICS

[2] Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. [J].

Costigan, Michael ;

Befort, Katia ;

Karchewski, Laurie ;

Griffin, Robert S. ;

D'Urso, Donatella ;

Allchorne, Andrew ;

Sitarski, Joanne ;

Mannion, James W. ;

Pratt, Richard E. ;

Woolf, Clifford J. .

BMC NEUROSCIENCE, 2002, 3 (1)

[3] Genetic basis for individual variations in pain perception and the development of a chronic pain condition [J].

Diatchenko, L ;

Slade, GD ;

Nackley, AG ;

Bhalang, K ;

Sigurdsson, A ;

Belfer, I ;

Goldman, D ;

Xu, K ;

Shabalina, SA ;

Shagin, D ;

Max, MB ;

Makarov, SS ;

Maixner, W .

HUMAN MOLECULAR GENETICS, 2005, 14 (01) :135-143

[4] Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting [J].

Dupuy, Alain ;

Simon, Richard M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (02) :147-157

[5] Geographic and haplotype structure of candidate type 2 diabetes-susceptibility variants at the calpain-10 locus [J].

Fullerton, SM ;

Bartoszewicz, A ;

Ybazeta, G ;

Horikawa, Y ;

Bell, GI ;

Kidd, KK ;

Cox, NJ ;

Hudson, RR ;

Di Rienzo, A .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (05) :1096-1106

[6] The structure of haplotype blocks in the human genome [J].

Gabriel, SB ;

Schaffner, SF ;

Nguyen, H ;

Moore, JM ;

Roy, J ;

Blumenstiel, B ;

Higgins, J ;

DeFelice, M ;

Lochner, A ;

Faggart, M ;

Liu-Cordero, SN ;

Rotimi, C ;

Adeyemo, A ;

Cooper, R ;

Ward, R ;

Lander, ES ;

Daly, MJ ;

Altshuler, D .

SCIENCE, 2002, 296 (5576) :2225-2229

[7] Cluster analysis of multiple experimental pain modalities [J].

Hastie, BA ;

Riley, JL ;

Robinson, ME ;

Glover, T ;

Campbell, CM ;

Staud, R ;

Fillingim, RB .

PAIN, 2005, 116 (03) :227-237

[8] Case-control studies in the genomic era: a clinician's guide [J].

Healy, Daniel G. .

LANCET NEUROLOGY, 2006, 5 (08) :701-707

[9] Genetic predictors for acute experimental cold and heat pain sensitivity in humans [J].

Kim, H. ;

Mittal, D. P. ;

Iadarola, M. J. ;

Dionne, R. A. .

JOURNAL OF MEDICAL GENETICS, 2006, 43 (08)

[10] Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament [J].

Kim, HS ;

Neubert, JK ;

Miguel, AS ;

Xu, K ;

Krishnaraju, RK ;

Iadarola, MJ ;

Goldman, D ;

Dionne, RA .

PAIN, 2004, 109 (03) :488-496