Guidelines for prescribing azathioprine in dermatology

被引：92
作者：
Anstey, AV
Wakelin, S
Reynolds, NJ
机构：
[1] Royal Gwent Hosp, Dept Dermatol, Newport NP20 2UB, Gwent, Wales
[2] St Marys Hosp, Dept Dermatol, London W2 1NY, England
[3] Newcastle Univ, Sch Clin & Lab Sci, Dept Dermatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2004年 / 151卷 / 06期
关键词：
D O I：
10.1111/j.1365-2133.2004.06323.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Azathioprine has been available as an immunosuppressive agent for over 40 years, and current routine usage in dermatology is not restricted to licensed indications. Advances in understanding the metabolic fate of azathioprine have led to significant changes in prescribing practice and toxicity monitoring by U.K. dermatologists. The current state of knowledge concerning the use of azathioprine in dermatology is summarized, with identification of strength of evidence. Clinical indications and contraindications for azathioprine usage in dermatology are identified. Evidence-based recommendations are made for routine safety monitoring of patients treated with azathioprine, including pretreatment assessment of red blood cell thiopurine methyltransferase activity.
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收藏
页码：1123 / 1132
页数：10
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