The Role of DNA Repair in Genomic Instability of Multiple Myeloma

被引：6

作者：

Ali, Jana Yasser Hafez ^{[1
,2
]}

Fitieh, Amira Mohammed ^{[1
,2
]}

Ismail, Ismail Hassan ^{[1
,2
]}

机构：

[1] Cairo Univ, Fac Sci, Biophys Dept, Giza 12613, Egypt

[2] Univ Alberta, Fac Med & Dent, Dept Oncol, 11560 Univ Ave, Edmonton, AB T6G 1Z2, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 10期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

multiple myeloma; DNA repair; genomic instability; DNA damage response; myeloma therapeutics; BASE EXCISION-REPAIR; CROSS-LINK REPAIR; HOMOLOGOUS RECOMBINATION; MISMATCH REPAIR; MICROSATELLITE INSTABILITY; IMMUNOMODULATORY DRUGS; DAMAGE RESPONSE; PATHWAY; CELLS; GENE;

D O I：

10.3390/ijms23105688

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role they play in MM progression and drug resistance. This review highlights how unrepaired DNA damage due to aberrant DNA repair response in MM exacerbates genomic instability and chromosomal abnormalities, enabling MM progression and drug resistance.

引用

页数：27

共 132 条

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