MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting

被引：202

作者：

Yao, Qing ^{[1
,2
]}

Kou, Longfa ^{[3
,4
]}

Tu, Ying ^{[1
]}

Zhu, Lin ^{[1
]}

机构：

[1] Texas A&M Univ, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, Kingsville, TX 78363 USA

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

[4] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2018年 / 39卷 / 08期

关键词：

CELL-PENETRATING PEPTIDES; MULTIFUNCTIONAL POLYMERIC MICELLES; IRON-OXIDE NANOPARTICLES; MATRIX METALLOPROTEINASES; IN-VIVO; GENE DELIVERY; CANCER-THERAPY; ANTICANCER ACTIVITY; ANTITUMOR EFFICACY; LIPOSOMAL CONTENTS;

D O I：

10.1016/j.tips.2018.06.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and therapeutic targets. Recently, MMPs have been investigated as robust tumor microenvironmental stimuli for 'smart' MMP-responsive drug delivery and tumor targeting and have shown great potential in cancer diagnosis and therapy. In this article, we review the newly emerging MMP-responsive strategies and major MMP-responsive nanomaterials and nanocarriers used for tumor-targeted delivery of drugs and imaging agents at the tissue, cellular, and intracellular levels. We also discuss the challenges and critical considerations in their development and clinical translation.

引用

页码：766 / 781

页数：16

共 93 条

[1]

[Anonymous], 2017, J NATL CANC I

[2] Release of Liposomal Contents by Cell-Secreted Matrix Metalloproteinase-9 [J].

Banerjee, Jayati ;

Hanson, Andrea J. ;

Gadam, Bhushan ;

Elegbede, Adekunle I. ;

Tobwala, Shakila ;

Ganguly, Bratati ;

Wagh, Anil V. ;

Muhonen, Wallace W. ;

Law, Benedict ;

Shabb, John B. ;

Srivastava, D. K. ;

Mallik, Sanku .

BIOCONJUGATE CHEMISTRY, 2009, 20 (07) :1332-1339

[3] Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy [J].

Biju, Vasudevanpillai .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (03) :744-764

[4] Principles of nanoparticle design for overcoming biological barriers to drug delivery [J].

Blanco, Elvin ;

Shen, Haifa ;

Ferrari, Mauro .

NATURE BIOTECHNOLOGY, 2015, 33 (09) :941-951

[5] Stimuli-Responsive Nanomaterials for Biomedical Applications [J].

Blum, Angela P. ;

Kammeyer, Jacquelin K. ;

Rush, Anthony M. ;

Callmann, Cassandra E. ;

Hahn, Michael E. ;

Gianneschi, Nathan C. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (06) :2140-2154

[6] Readily adaptable release kinetics of prodrugs using protease-dependent reversible PEGylation [J].

Bottger, Roland ;

Knappe, Daniel ;

Hoffmann, Ralf .

JOURNAL OF CONTROLLED RELEASE, 2016, 230 :88-94

[7]

Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/NNANO.2011.166, 10.1038/nnano.2011.166]

[8] Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases [J].

Cauwe, Benedicte ;

Opdenakker, Ghislain .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 45 (05) :351-423

[9] Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers [J].

Champion, Julie A. ;

Katare, Yogesh K. ;

Mitragotri, Samir .

JOURNAL OF CONTROLLED RELEASE, 2007, 121 (1-2) :3-9

[10] Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor xenograft model [J].

Chau, Y ;

Dang, NM ;

Tan, FE ;

Langer, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 95 (03) :542-551

← 1 2 3 4 5 6 7 8 9 10 →