Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis

被引：8
|
作者：
Zha, Quanbin [1 ]
Wu, Xi [2 ]
Zhang, Jingxin [3 ]
Xu, Tingting [2 ]
Shi, YongKang [1 ]
Sun, Yayun [4 ]
Fang, Yuan [2 ]
Gu, Yunru [2 ]
Ma, Pei [1 ,2 ]
Shu, Yongqian [1 ,2 ,5 ,6 ]
Tian, Shengwang [1 ]
机构：
[1] Jiangsu Univ, Jintan Hosp, Dept Oncol, Changzhou 213200, Peoples R China
[2] Nanjing Med Univ, Affifiliated Hosp 1, Dept Oncol, Nanjing 210029, Peoples R China
[3] Nanjing Med Univ, Zhenjiang Clin Sch, Affifiliated Peoples Hosp, Dept Gen Surg,Jiangsu Univ, Zhenjiang 212002, Jiangsu, Peoples R China
[4] Jiangsu Univ, Jintan Hosp, Dept Neurol, Changzhou 213200, Peoples R China
[5] Nanjing Med Univ, Sir Run Run Hosp, Dept Oncol, Nanjing 210029, Peoples R China
[6] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 210029, Peoples R China
来源：
CELL DEATH DISCOVERY | 2022年 / 8卷 / 01期
关键词：
CIRCULAR RNA; TRANSLATION; IDENTIFICATION;
D O I：
10.1038/s41420-022-00954-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.
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页数：9
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