Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006

被引：38

作者：

Lipatov, Aleksandr S.

Evseenko, Vasily A.

Yen, Hui-Ling

Zaykovskaya, Anna V.

Durimanov, Alexander C.

Zolotykh, Sergey I.

Netesov, Sergey V.

Drozdov, Ilya G.

Onishchenko, Gennadiy G.

Webster, Robert G.

Shestopalov, Alexander M.

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA

[2] Fed State Res Inst, Res Ctr Virol & Biotechnol Vector, Koltsov, Novosibirsk, Russia

[3] Fed Serv Surveillance Consumer Rights Protect & H, Moscow, Russia

来源：

EMERGING INFECTIOUS DISEASES | 2007年 / 13卷 / 04期

关键词：

D O I：

10.3201/eid1304.061266

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005-February 2006. Full genome sequences showed high homology to Qinghai-like influenza (H5N1) viruses. Phylogenetic analysis not only showed a close genetic relationship between the H5N1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. Analysis of deduced amino acid sequences of the M2 and neuraminidase proteins showed that all isolates are potentially sensitive to currently available antiviral drugs. Pathogenicity testing showed that all studied viruses were highly pathogenic in chickens; for 3 isolates tested in mice and 2 tested in ferrets, pathogenicity was heterogeneous. Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2.

引用

页码：539 / 546

页数：8

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