Non-Coding RNAs in Cartilage Development: An Updated Review

被引：62
作者：
Razmara, Ehsan [1 ]
Bitaraf, Amirreza [2 ]
Yousefi, Hassan [3 ]
Nguyen, Tina H. [3 ]
Garshasbi, Masoud [1 ]
Cho, William Chi-shing [4 ]
Babashah, Sadegh [2 ]
机构：
[1] Tarbiat Modares Univ, Fac Med Sci, Dept Med Genet, POB 14115-111, Tehran, Iran
[2] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-111, Tehran, Iran
[3] LSUHSC Sch Med, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA
[4] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 18期
关键词：
chondrogenesis; non-coding RNAs; lncRNAs; microRNAs; cartilage development; MESENCHYMAL STEM-CELLS; PROMOTES CHONDROGENIC DIFFERENTIATION; CONTROLS CHONDROCYTE HYPERTROPHY; EXTRACELLULAR-MATRIX SYNTHESIS; ARTICULAR-CARTILAGE; OSTEOARTHRITIS PROGRESSION; HISTONE DEACETYLASE-4; SYNOVIAL-FLUID; NERVOUS-SYSTEM; PROLIFERATION;
D O I：
10.3390/ijms20184475
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the development of the skeleton, the long bones are arising from the process of endochondral ossification (EO) in which cartilage is replaced by bone. This complex process is regulated by various factors including genetic, epigenetic, and environmental elements. It is recognized that DNA methylation, higher-order chromatin structure, and post-translational modifications of histones regulate the EO. With emerging understanding, non-coding RNAs (ncRNAs) have been identified as another mode of EO regulation, which is consist of microRNAs (miRNAs or miRs) and long non-coding RNAs (lncRNAs). There is expanding experimental evidence to unlock the role of ncRNAs in the differentiation of cartilage cells, as well as the pathogenesis of several skeletal disorders including osteoarthritis. Cutting-edge technologies such as epigenome-wide association studies have been employed to reveal disease-specific patterns regarding ncRNAs. This opens a new avenue of our understanding of skeletal cell biology, and may also identify potential epigenetic-based biomarkers. In this review, we provide an updated overview of recent advances in the role of ncRNAs especially focus on miRNA and lncRNA in the development of bone from cartilage, as well as their roles in skeletal pathophysiology.
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页数：26
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