Bioimaging By Secondary Ion Mass Spectrometry

被引：4

作者：

Cai, Lesi ^{[1
]}

Xia, Meng-Chan ^{[1
]}

Li, Zhanping ^{[1
,2
]}

Zhang, Sichun ^{[1
]}

Zhang, Xinrong ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

来源：

PROGRESS IN CHEMISTRY | 2021年 / 33卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

SIMS; mass spectrometry imaging; bio-analysis; single-cell analysis; life science; SINGLE-CELL LEVEL; TOF-SIMS; ELECTROSPRAY-IONIZATION; SUBCELLULAR-DISTRIBUTION; SPATIAL-RESOLUTION; SAMPLE PREPARATION; DNA MICROARRAYS; SKELETAL-MUSCLE; LIPID VESICLES; TISSUE;

D O I：

10.7536/PC200458

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Secondary ion mass spectrometry (SIMS). as the highest spatial resolution mass spectrometry imaging technique. holds label-free. high sensitivity. multi-component detection advantages and sub-micron high spatial resolution imaging advantage, providing new analysis method to study life science problems. SIMS has been widely used in cell biology, tissue pathological physiology. biological medicine. clinical medicine and other fields. This paper reviews the progress of SIMS imaging in biological tissue. cell. bionic biofilm and other bio-samples.

引用

页码：97 / 110

页数：14

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