NAD(P)H:quinone oxidoreductase 1 (NQO1):: chemoprotection, bioactivation, gene regulation and genetic polymorphisms

被引：527

作者：

Ross, D

Kepa, JK

Winski, SL

Beall, HD

Anwar, A

Siegel, D

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Pharm, Dept Pharmaceut Sci, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Ctr Canc, Denver, CO 80262 USA

[3] Univ Montana, Sch Pharm, Dept Pharmaceut Sci, Missoula, MT 59812 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2000年 / 129卷 / 1-2期

关键词：

NQO1 (NAD(P)H : quinone oxidoreductase 1); quinone; vitamin E; ubiquinone; antitumor quinones; gene regulation; antioxidant response element (ARE) polymorphisms;

D O I：

10.1016/S0009-2797(00)00199-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones, This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of antioxidant forms of ubiquinone and vitamin E, Bioactivation reactions catalyzed by NQO1 are also summarized and the development of new antitumor agents for the therapy of solid tumors with marked NQO1 content is reviewed. NQO1 gene regulation and the role of the antioxidant response element and the xenobiotic response element in transcriptional regulation is summarized. An overview of genetic polymorphisms in NQO1 is presented and biological significance for chemoprotection, cancer susceptibility and antitumor drug action is discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：77 / 97

页数：21

共 151 条

[31]

Ernster L, 1967, Methods in enzymology, P309, DOI DOI 10.1016/0076-6879(67)10059-1

[32]

Fourie J, 1999, CLIN CANCER RES, V5, p3781S

[33] Novel quinolinequinone antitumor agents:: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1) [J].