Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

被引：3

作者：

Lu, Lunjie ^{[1
,2
]}

Zhou, Jun ^{[3
]}

Zhang, Jingying ^{[2
]}

Che, Jun ^{[4
]}

Jiao, Yang ^{[2
]}

Zhang, Yusong ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Oncol, Suzhou 215004, Peoples R China

[2] Soochow Univ, Sch Med, Sch Radiat Med & Protect, Dept Radiat Genet, Suzhou 215123, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Suzhou Kowloon Hosp, Dept Emergency, Suzhou 215000, Peoples R China

[4] Jiangnan Univ, Affiliated Hosp, Dept Radiat Oncol, Wuxi 214062, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2016年 / 2016卷

基金：

美国国家科学基金会;

关键词：

D-GALACTOSAMINE; TGF-BETA; PATHWAYS; PERSPECTIVES; INFLAMMATION; FAILURE; TARGET; ROLES;

D O I：

10.1155/2016/4097398

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine-(D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.

引用

页数：8

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