The Biomolecular Interaction Network Database and related tools 2005 update

被引:429
作者
Alfarano, C
Andrade, CE
Anthony, K
Bahroos, N
Bajec, M
Bantoft, K
Betel, D
Bobechko, B
Boutilier, K
Burgess, E
Buzadzija, K
Cavero, R
D'Abreo, C
Donaldson, I
Dorairajoo, D
Dumontier, MJ
Dumontier, MR
Earles, V
Farrall, R
Feldman, H
Garderman, E
Gong, Y
Gonzaga, R
Grytsan, V
Gryz, E
Gu, V
Haldorsen, E
Halupa, A
Haw, R
Hrvojic, A
Hurrell, L
Isserlin, R
Jack, F
Juma, F
Khan, A
Kon, T
Konopinsky, S
Le, V
Lee, E
Ling, S
Magidin, M
Moniakis, J
Montojo, J
Moore, S
Muskat, B
Ng, I
Paraiso, JP
Parker, B
Pintilie, G
Pirone, R
机构
[1] Mt Sinai Hosp, Blueprint Initiat, Toronto, ON M5G 1X5, Canada
[2] Natl Univ Singapore, Dept Sci Biol, Blueprint Initiat Asia, Singapore 117543, Singapore
[3] Univ British Columbia, Bioinformat Ctr, Vancouver, BC V5Z 4H4, Canada
关键词
D O I
10.1093/nar/gki051
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Biomolecular Interaction Network Database (BIND) (http://bind.ca) archives biomolecular interaction, reaction, complex and pathway information. Our aim is to curate the details about molecular interactions that arise from published experimental research and to provide this information, as well as tools to enable data analysis, freely to researchers worldwide. BIND data are curated into a comprehensive machine-readable archive of computable information and provides users with methods to discover interactions and molecular mechanisms. BIND has worked to develop new methods for visualization that amplify the underlying annotation of genes and proteins to facilitate the study of molecular interaction networks. BIND has maintained an open database policy since its inception in 1999. Data growth has proceeded at a tremendous rate, approaching over 100000 records. New services provided include a new BIND Query and Submission interface, a Standard Object Access Protocol service and the Small Molecule Interaction Database (http://smid.blueprint.org) that allows users to determine probable small molecule binding sites of new sequences and examine conserved binding residues.
引用
收藏
页码:D418 / D424
页数:7
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