Pushing and Pulling in Prokaryotic DNA Segregation

被引：246

作者：

Gerdes, Kenn ^{[1
]}

Howard, Martin ^{[2
]}

Szardenings, Florian ^{[1
]}

机构：

[1] Newcastle Univ, Ctr Bacterial Cell Biol, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4AX, Tyne & Wear, England

[2] John Innes Inst, Dept Computat & Syst Biol, Norwich NR4 7UH, Norfolk, England

来源：

CELL | 2010年 / 141卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ESCHERICHIA-COLI CHROMOSOME; MICROTUBULE DYNAMIC INSTABILITY; DIVISION SITE SELECTION; UNIT-COPY MINIPLASMIDS; SEPARATE CELL HALVES; ACTIN-LIKE FILAMENTS; PROTEIN SPO0J PARB; BACILLUS-SUBTILIS; PLASMID SEGREGATION; P1; PLASMID;

D O I：

10.1016/j.cell.2010.05.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.

引用

页码：927 / 942

页数：16

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