TETRACYCLINES AND GLYCYLCYCLINES: AN OVERVIEW.

被引：36

作者：

Pereira-Maia, Elene Cristina ^{[1
]}

Silva, Priscila Pereira ^{[1
]}

de Almeida, Wagner Batista ^{[1
]}

dos Santos, Helio Ferreira ^{[2
]}

Marcial, Bruna Luana ^{[2
]}

Ruggiero, Reinaldo ^{[3
]}

Guerra, Wendell ^{[3
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil

[3] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 03期

关键词：

tetracyclines; glycylcyclines; antibacterial activity; BIOLOGICAL-FLUIDS; SPECTROSCOPIC PROPERTIES; PALLADIUM(II) COMPLEXES; ANTIBACTERIAL ACTIVITY; COPPER(II) COMPLEXES; IN-VITRO; OXYTETRACYCLINE; DOXYCYCLINE; ANHYDROTETRACYCLINE; TIGECYCLINE;

D O I：

10.1590/S0100-40422010000300038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

TETRACYCLINES AND GLYCYLCYCLINES: AN OVERVIEW. Tetracyclines exhibits activity to a broad range of Gram-negative and Gram-positive bacteria and this fact allied to the low toxicity, low cost, and the advantage of administration by oral route led to their indiscriminate use, which caused the appearance of bacterial resistance to these agents, wich has restricted its clinical utility, though new applications have emerged. On the other hand, the glycylcyclines, semi-synthetic products are similar to tetracyclines. which are active against many bacteria resistant to tetracycline and other classes of antibiotics. The purpose of this paper is to give an overview of this important class of antibiotics focusing on its coordination chemistry and possible applications.

引用

页码：700 / 706

页数：7

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