The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

被引:63
作者
Marchese, Leticia [1 ]
Nascimento, Janaina de Freitas [1 ]
Damasceno, Flavia Silva [1 ]
Bringaud, Frederic [2 ]
Michels, Paul A. M. [3 ,4 ]
Silber, Ariel Mariano [1 ]
机构
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Lab Biochem Tryps LaBTryps, Av Lineu Prestes 1374, BR-05508000 Sao Paulo, SP, Brazil
[2] Univ Bordeaux, Lab Microbiol Fondamentale & Pathogen MFP, CNRS, UMR 5234, 146 Rue Leo Saignat,Batiment 3A, F-33076 Bordeaux, France
[3] Univ Edinburgh, Ctr Immun Infect & Evolut, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian, Scotland
[4] Univ Edinburgh, Ashworth Labs, Sch Biol Sci, Ctr Translat & Chem Biol, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian, Scotland
来源
PATHOGENS | 2018年 / 7卷 / 02期
基金
英国生物技术与生命科学研究理事会;
关键词
amino acid metabolism; amino acid uptake; bioenergetics; stress management; autophagy; host-parasite interaction; S-ADENOSYLMETHIONINE DECARBOXYLASE; BROAD-SPECIFICITY AMINOTRANSFERASE; LEISHMANIA-DONOVANI AMASTIGOTES; NOVO PYRIMIDINE BIOSYNTHESIS; CYSTATHIONINE BETA-SYNTHASE; CONTRACTILE VACUOLE COMPLEX; GLYCINE-CLEAVAGE COMPLEX; BLOOD-STREAM FORMS; BIOCHEMICAL-CHARACTERIZATION; L-PROLINE;
D O I
10.3390/pathogens7020036
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
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页数:45
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