Dynamics of the Multipathway Regulation of the Vasodilator Bold Effect Induced by a Nerve Impulse: A Kinetic Model of the Neurovascular Coupling Process

被引：5
作者：
Varfolomeev, Sergey D. [1 ]
Bykov, Valeriy, I [2 ]
Semenova, Nataliya A. [2 ]
Tsybenova, Svetlana B. [2 ]
机构：
[1] Lomonosov Moscow State Univ, Inst Phys & Chem Grounds Neuronet Funct & Artific, Dept Chem, Moscow 119991, Russia
[2] Emanuel Inst Biochem Phys, Moscow 119334, Russia
来源：
ACS CHEMICAL NEUROSCIENCE | 2021年 / 12卷 / 12期
基金：
俄罗斯科学基金会;
关键词：
BOLD signal; kinetic model; dynamic process; indomethacin; neurovascular coupling; multipathway mechanism; catalytic activity of enzyme; BLOOD OXYGENATION; BRAIN; INHIBITION; MRI; INDOMETHACIN; POLYMORPHISM; MECHANISM; SIGNALS; ENZYMES; FMRI;
D O I：
10.1021/acschemneuro.1c00214
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A kinetic model of the dynamics of a multipathway mechanism of neurovascular coupling induced by nerve impulses was constructed. The model calculations were compared with experimental data on the changes in the blood oxygen level dependent signal during sensory-motor and visual excitation before and after the use of the nonsteroidal anti-inflammatory drug indomethacin. The influence of the catalytic activity of key enzymes on the dynamics of the neurovascular response in the proposed model is shown. The multipathway mechanism of the biochemical reactions provides stability of the neurovascular coupling during various possible catalytic activities of the key enzymes in the process.
引用
收藏
页码：2202 / 2208
页数：7
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