Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

被引：332

作者：

Ashcroft, GS

Lei, KJ

Jin, WW

Longenecker, G

Kulkarni, AB

Greenwell-Wild, T

Hale-Donze, H

McGrady, G

Song, XY

Wahl, SM

机构：

[1] Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Dent & Craniofacial Res, Gene Targeting Facil, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/80489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor with anti-microbial properties found in mucosal fluids. It is expressed during cutaneous wound healing. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in this process. We have generated mice null for the gene encoding SLPI (Slpi), which show impaired cutaneous wound healing with increased inflammation and elastase activity. The altered inflammatory profile involves enhanced activation of local TGF-beta in Slpi-null mice. We propose that SLPI is a pivotal endogenous factor necessary for optimal wound healing.

引用

页码：1147 / 1153

页数：7

共 45 条

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