Tumor-suppressing roles of miR-214 and miR-218 in breast cancer

被引：76

作者：

Liu, Bo ^{[1
]}

Tian, Yanfeng ^{[1
]}

Li, Fang ^{[1
]}

Zhao, Zengren ^{[1
]}

Jiang, Xia ^{[1
]}

Zhai, Congjie ^{[1
]}

Han, Xiaodong ^{[1
]}

Zhang, Like ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 1, Dept Gen Surg, Donggang Rd 89, Shijiazhuang 050031, Hebei, Peoples R China

来源：

ONCOLOGY REPORTS | 2016年 / 35卷 / 06期

关键词：

breast cancer; microRNA; miR-214; miR-218; cell proliferation; cell apoptosis; cell cycle; cell migration; CELL-PROLIFERATION; DOWN-REGULATION; PROMOTES APOPTOSIS; MICRORNA-218; MIGRATION; INVASION; GROWTH; EXPRESSION; CARCINOMA; THERAPY;

D O I：

10.3892/or.2016.4749

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in breast cancer have not been elucidated completely. The present study evaluated the expression and biological function of miR-214 and miR-218 in human breast cancer. Our results revealed,that the expression of miR-214 and miR-218 were significantly decreased in breast cancer tissues compared with adjacent tissues. The aberrant expression of miR-214 and miR-218 were negatively associated with Ki-67, and the miR-218 expression was positively associated with progesterone receptor (PR) in breast cancer tissues. In vitro, the cell proliferation and migration were decreased, cell apoptosis was induced, and cell cycle was also disturbed in miR-214 or miR-218 overexpressed breast cancer cells. Our results demonstrated that miR-214 and miR-218 function as tumor suppressors in breast cancer, and may become biomarkers and potential therapeutic targets in breast cancer.

引用

页码：3178 / 3184

页数：7

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