Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP

被引：79

作者：

Zusev, M ^{[1
]}

Gozes, I ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel

来源：

REGULATORY PEPTIDES | 2004年 / 123卷 / 1-3期

基金：

以色列科学基金会;

关键词：

activity-dependent neuroprotective protein; vasoactive intestinal peptide; pituitary adenylate cyclase-activating polypeptide; VIP/PACAP receptors; VPAC1; VPAC2 and PAC1;

D O I：

10.1016/j.regpep.2004.05.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activity-dependent neuroprotective protein (ADNP) was shown to be a vasoactive intestinal peptide (VIP) responsive gene in astrocytes derived from the cerebral cortex of newbom rats. The present study was set out to identify VIP receptors that are associated with increases in ADNP expression in developing astrocytes. Using VIP analogues specific for the VPAC1 and the VPAC2 receptors, it was discovered that VIP induced changes in ADNP expression in astrocytes via the VPAC2 receptor. The constitutive synthesis of ADNP and VPAC2 was shown to be age-dependent and increased as the astrocyte culture developed. Pituitary adenylate cyclase-activating polypeptide (PACAP) also induced changes in ADNP expression. The apparent changes induced by VIP and PACAP on ADNP expression were developmentally dependent, and while stimulating expression in young astrocytes, an inhibition was demonstrated in older cultures. In conclusion, VIP, PACAP and the VPAC2 receptor may all contribute to the regulation of ADNP gene expression in the developing astrocyte. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：33 / 41

页数：9

共 52 条

[1] Pituitary adenylate cyclase-activating polypeptide inhibits collagen-induced arthritis: An experimental immunomodulatory therapy [J].

Abad, C ;

Martinez, C ;

Leceta, J ;

Gomariz, RP ;

Delgado, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (06) :3182-3189

[2] PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) AND ITS RECEPTORS - NEUROENDOCRINE AND ENDOCRINE INTERACTION [J].

ARIMURA, A ;

SHIODA, S .

FRONTIERS IN NEUROENDOCRINOLOGY, 1995, 16 (01) :53-88

[3] PACAP FUNCTIONS AS A NEUROTROPHIC FACTOR [J].

ARIMURA, A ;

SOMOGYVARIVIGH, A ;

WEILL, C ;

FIORE, RC ;

TATSUNO, I ;

BAY, V ;

BRENNEMAN, DE .

MODELS OF NEUROPEPTIDE ACTION, 1994, 739 :228-243

[4] Identification of VIP/PACAP receptors on rat astrocytes using antisense oligodeoxynucleotides [J].

Ashur-Fabian, O ;

Giladi, E ;

Brenneman, DE ;

Gozes, I .

JOURNAL OF MOLECULAR NEUROSCIENCE, 1997, 9 (03) :211-222

[5] Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures [J].

Ashur-Fabian, O ;

Giladi, E ;

Furman, S ;

Steingart, RA ;

Wollman, Y ;

Fridkin, M ;

Brenneman, DE ;

Gozes, I .

NEUROSCIENCE LETTERS, 2001, 307 (03) :167-170

[6] Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide [J].

Bassan, M ;

Zamostiano, R ;

Davidson, A ;

Pinhasov, A ;

Giladi, E ;

Perl, O ;

Bassan, H ;

Blat, C ;

Gibney, G ;

Glazner, G ;

Brenneman, DE ;

Gozes, I .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (03) :1283-1293

[7]

Blondel O, 2000, J NEUROSCI, V20, P8012

[8] VASOACTIVE-INTESTINAL-PEPTIDE AND ELECTRICAL-ACTIVITY INFLUENCE NEURONAL SURVIVAL [J].

BRENNEMAN, DE ;

EIDEN, LE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :1159-1162

[9] NONNEURONAL CELLS MEDIATE NEUROTROPHIC ACTION OF VASOACTIVE-INTESTINAL-PEPTIDE [J].

BRENNEMAN, DE ;

NEALE, EA ;

FOSTER, GA ;

DAUTREMONT, SW ;

WESTBROOK, GL .

JOURNAL OF CELL BIOLOGY, 1987, 104 (06) :1603-1610

[10] A femtomolar-acting neuroprotective peptide [J].

Brenneman, DE ;

Gozes, I .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (10) :2299-2307

← 1 2 3 4 5 6 →