Click glycoconjugation of per-azido- and alkynyl-functionalized β-peptides built from aspartic acid

被引：10

作者：

Barra, Marielle ^{[1
,2
]}

Roy, Olivier ^{[1
,2
]}

Traikia, Mounir ^{[1
,2
]}

Taillefumier, Claude ^{[1
,2
]}

机构：

[1] Univ Blaise Pascal, Lab SEESIB, Clermont Univ, F-63000 Clermont Ferrand, France

[2] CNRS, UMR 6504, Lab SEESIB, F-63177 Aubiere, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 13期

关键词：

HOST-DEFENSE PEPTIDES; SECONDARY STRUCTURES; PROTEOLYTIC STABILITY; HEMOLYTIC ACTIVITIES; BUILDING-BLOCKS; GAMMA-PEPTIDES; SOLID-PHASE; AMINO; DESIGN; CYCLOADDITION;

D O I：

10.1039/b923275c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Azide- and alkynyl-containing homo-beta(3)-peptides, of up to six residues in length, were synthesised in solution from aspartic acid. Their subsequent conjugation with monosaccharides bearing an azide or a terminal alkyne function was efficiently achieved by copper-mediated cycloadditions leading to two novel families of small glycoclusters. These compounds represent ideal tools to explore carbohydrate-mediated multivalent interactions.

引用

页码：2941 / 2955

页数：15

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