Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population

被引：1

作者：

Yoo, Seung Soo ^{[1
]}

Hong, Mi Jeong ^{[2
]}

Choi, Jin Eun ^{[2
]}

Lee, Jang Hyuck ^{[2
]}

Baek, Sun Ah ^{[2
]}

Lee, Won Kee ^{[3
]}

Lee, So Yeon ^{[1
]}

Lee, Shin Yup ^{[1
]}

Lee, Jaehee ^{[1
]}

Cha, Seung Ick ^{[1
]}

Kim, Chang Ho ^{[1
]}

Cho, Sukki ^{[4
]}

Park, Jae Yong ^{[1
,2
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 807 Hoguk Ro, Daegu 41404, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 41404, South Korea

[4] Seoul Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2016年 / 31卷 / 03期

关键词：

Wnt; Lung Neoplasms; Polymorphisms; Survival; RECURRENCE; ACTIVATION; EXPRESSION; SUBSET;

D O I：

10.3346/jkms.2016.31.3.463

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease -free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease -free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.

引用

页码：463 / +

页数：7

共 18 条

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