Galloyl group is not necessary for a sedative effect of catechin through GABAergic system

被引：5

作者：

Adachi, Nami

Tomonaga, Shozo

Suenaga, Rie

Denbow, D. Michael

Furuse, Mitsuhiro ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & Marine Bioresources, Fukuoka 8128581, Japan

[2] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2007年 / 4卷 / 03期

关键词：

(-)-epigallocatechin gallate; (-)-epigallocatechin; gamma-aminobutyric acid receptors; brain; intracerebroventricular injection; chick;

D O I：

10.2174/157018007780077444

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(-)-Epigallocatechin gallate (EGCG) has a sedative effect acting through gamma-aminobutyric acid (GABA)(A) receptors in the brain, but it is unclear what structural components of the molecule are necessary for its action. To investigate the necessity of the galloyl group on the sedation induced by EGCG, the effect of EGCG was compared with (-)-epigallocatechin (EGC) in which the galloyl group is removed from EGCG. Intracerebroventricular (i.c.v.) injection of EGC, as well as EGCG, induced, and the effect of EGC were blocked by the GABA(A) receptor antagonist picrotoxin. It is concluded that catechins have a sedative effect acting through GABA(A) receptors under an acute stress condition irrespective of the presence of the galloyl group.

引用

页码：163 / 167

页数：5

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