Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

被引：96
作者：
Riela, Serena [1 ]
Massaro, Marina [1 ]
Colletti, Carmelo G. [1 ]
Bommarito, Alessandra [2 ]
Giordano, Carla [2 ]
Milioto, Stefana [3 ]
Noto, Renato [1 ]
Poma, Paola [4 ]
Lazzara, Giuseppe [3 ]
机构：
[1] Univ Palermo, Dipartimento STEBICEF, Sez Chim, Viale Sci,Parco Orleans 2,Ed 17, I-90128 Palermo, Italy
[2] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Sez Endocrinol, I-90127 Palermo, Italy
[3] Univ Palermo, Dipartimento Fis & Chim, I-90128 Palermo, Italy
[4] Univ Palermo, Area Funz Farmacol, Dipartimento Sci Promoz Salute & Materno Infantil, I-90127 Palermo, Italy
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 475卷 / 1-2期
关键词：
Halloysite nanotubes; Triazolium salts; Drug carrier; Curcumin; In vitro anticancer activity; MEDIATED RADICAL POLYMERIZATION; CLAY NANOTUBES; IN-VITRO; MICROWAVE IRRADIATION; SCHIFF-BASES; CANCER-CELLS; TUMOR-GROWTH; CURCUMIN; NANOPARTICLES; RELEASE;
D O I：
10.1016/j.ijpharm.2014.09.019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means dynamic light scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by thermogravimetric analysis (TGA) measurements, while the morphology was investigated by scanning electron microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines. (C) 2014 Elsevier B. V. All rights reserved.
引用
收藏
页码：613 / 623
页数：11
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