The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

被引：25

作者：

Polonikov, Alexey V. ^{[1
]}

Yarosh, Sergey L. ^{[3
]}

Kokhtenko, Elena V. ^{[2
]}

Starodubova, Nina I. ^{[3
]}

Pakhomov, Sergey P. ^{[4
]}

Orlova, Valentina S. ^{[4
]}

机构：

[1] Kursk State Med Univ, Dept Biol Med Genet & Ecol, Kursk 305041, Russia

[2] Kursk State Med Univ, Dept Zool & Theory Evolut, Kursk 305041, Russia

[3] Reg Perinatal Ctr, Family Planning & Reprod Hlth Clin, Kursk, Russia

[4] Belgorod State Univ, Dept Obstet & Gynecol, Belgorod, Russia

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 03期

关键词：

SUSCEPTIBILITY; POLYMORPHISMS; CANCER; POPULATION; CONJUGATION; HALOALKANES; METABOLISM; BACTERIAL; SPERM; GSTM1;

D O I：

10.1016/j.fertnstert.2009.11.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia. (Fertil Steril (R) 2010;94:1144-7. (C)2010 by American Society for Reproductive Medicine.)

引用

页码：1144 / 1147

页数：4

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