Roles of the Metabolic Syndrome, HDL Cholesterol, and Coronary Atherosclerosis in Subclinical Inflammation

被引:18
|
作者
Rein, Philipp [1 ,2 ,3 ]
Saely, Christoph H. [1 ,2 ,3 ]
Beer, Stefan [1 ,2 ,3 ]
Vonbank, Alexander [1 ,2 ,3 ]
Drexel, Heinz [1 ,2 ,3 ,4 ]
机构
[1] Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria
[2] Acad Teaching Hosp Feldkirch, Dept Med & Cardiol, Feldkirch, Austria
[3] Private Univ Principal Liechtenstein, Triesen, Liechtenstein
[4] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA
关键词
C-REACTIVE PROTEIN; ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; PREDICTORS; ANGINA; EXTENT; RISK;
D O I
10.2337/dc09-2376
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE- The metabolic syndrome (MetS) and coronary artery disease (CAD) frequently coincide; their individual contribution to inflammation is unknown. RESEARCH DESIGN AND METHODS- We enrolled 1,010 patients undergoing coronary angiography. Coronary stenoses >= 50% were considered significant. The MetS was defined according to American Heart Association revised National Cholesterol Education Program Adult Treatment Panel III criteria. RESULTS- C-reactive protein (CRP) did not differ between patients with significant CAD and subjects without significant CAD (P = 0.706) but was significantly higher in MetS patients than in those without MetS (P < 0.001). The MetS criteria low HDL cholesterol (P < 0.001), large waist (P < 0.001), high glucose (P < 0.001), and high blood pressure (P = 0.016), but not high triglycerides (P = 0.352), proved associated with CRP. When all MetS traits were considered simultaneously, only low HDL cholesterol proved independently associated with CRP (F = 44.19; P < 0.001). CONCLUSIONS- CRP is strongly associated with the MetS but not with coronary atherosclerosis. The association of the MetS with subclinical inflammation is driven by the low HDL cholesterol feature.
引用
收藏
页码:1853 / 1855
页数:3
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