Regulation of mRNA Translation and Stability by microRNAs

被引：2577

作者：

Fabian, Marc Robert ^{[1
,2
]}

Sonenberg, Nahum ^{[1
,2
]}

Filipowicz, Witold ^{[3
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3G 1Y6, Canada

[3] Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 | 2010年 / 79卷

基金：

加拿大健康研究院;

关键词：

Argonaute; deadenylation; GW182; microRNA; repression; MIRNA-MEDIATED REPRESSION; RIBOSOME ENTRY SITE; ENCEPHALOMYOCARDITIS VIRUS-RNA; POLY(A) BINDING-PROTEIN; INITIATION-FACTOR; POLY(A)-BINDING PROTEIN; LET-7; MICRORNA; IN-VITRO; P-BODIES; CAENORHABDITIS-ELEGANS;

D O I：

10.1146/annurev-biochem-060308-103103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pairing to the mRNA 3'-untranslated regions to repress protein synthesis by mechanisms that are not fully understood. In this review, we describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA-mediated repression. We discuss the multiple, often contradictory, mechanisms that miRNAs have been reported to use, which cause translational repression and mRNA decay. We also address the issue of cellular localization of miRNA-mediated events and a role for RNA-binding proteins in activation or relief of miRNA repression.

引用

页码：351 / 379

页数：29

共 189 条

[1] Translation of nonSTOP mRNA is repressed post-initiation in mammalian cells [J].

Akimitsu, Nobuyoshi ;

Tanaka, Junichi ;

Pelletier, Jerry .

EMBO JOURNAL, 2007, 26 (09) :2327-2338

[2] Molecular basis for target RNA recognition and cleavage by human RISC [J].

Ameres, Stefan Ludwig ;

Martinez, Javier ;

Schroeder, Renee .

CELL, 2007, 130 (01) :101-112

[3] A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies [J].

Andrei, MA ;

Ingelfinger, D ;

Heintzmann, R ;

Achsel, T ;

Rivera-Pomar, R ;

Lührmann, R .

RNA, 2005, 11 (05) :717-727

[4] Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing [J].

Azuma-Mukai, Asuka ;

Oguri, Hideo ;

Mituyama, Toutai ;

Qian, Zhi Rong ;

Asai, Kiyoshi ;

Siomi, Haruhiko ;

Siomi, Mikiko C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (23) :7964-7969

[5] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[6] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].

Bagga, S ;

Bracht, J ;

Hunter, S ;

Massirer, K ;

Holtz, J ;

Eachus, R ;

Pasquinelli, AE .

CELL, 2005, 122 (04) :553-563

[7] Functional Dissection of the Human TNRC6 (GW182-Related) Family of Proteins [J].

Baillat, David ;

Shiekhattar, Ramin .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (15) :4144-4155

[8] AU-rich elements and associated factors: are there unifying principles? [J].

Barreau, C ;

Paillard, L ;

Osborne, HB .

NUCLEIC ACIDS RESEARCH, 2005, 33 (22) :7138-7150

[9] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[10] MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes [J].

Behm-Ansmant, Isabelle ;

Rehwinkel, Jan ;

Doerks, Tobias ;

Stark, Alexander ;

Bork, Peer ;

Izaurralde, Elisa .

GENES & DEVELOPMENT, 2006, 20 (14) :1885-1898

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