Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease

被引：52
作者：
Chapman, T
McKeel, DW
Morris, JC
机构：
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
来源：
NEUROLOGY | 2000年 / 55卷 / 09期
关键词：
D O I：
10.1212/WNL.55.9.1396
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
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收藏
页码：1396 / 1397
页数：2
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