A new monoterpene-lactone with neuroprotective activity from corn silk

被引：12

作者：

Zhou, Wei-Yu ^{[1
]}

Lv, Tian-Ming ^{[1
]}

Hou, Zi-Lin ^{[1
]}

Bai, Ming ^{[1
]}

Lin, Bin ^{[2
]}

Huang, Xiao-Xiao ^{[1
]}

Song, Shao-Jiang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Nat Antitumor Drug Res & De, Shenyang, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang, Liaoning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 18期

关键词：

Corn silk; monoterpene-lactone; ECD calculation; neuroprotective effects;

D O I：

10.1080/14786419.2019.1689503

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new monoterpene-lactone (1) along with five known compounds (2-6) were isolated from corn silk. The structure of the new compound was elucidated based on comprehensive spectroscopic analyses and quantum chemical calculations of electronic circular dichroism (ECD) curves. All compounds were evaluated for their neuroprotective effects against H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). As a result, compound 1 exhibited weak neuroprotective activity.

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收藏

页码：3142 / 3145

页数：4

相关论文

共 13 条

[1] AURANTIAMIDES - A NEW CLASS OF MODIFIED DIPEPTIDES FROM PIPER-AURANTIACUM [J].

BANERJI, A ;

RAY, R .

PHYTOCHEMISTRY, 1981, 20 (09) :2217-2220

[2] Two new compounds from cultures of the basidiomycete Antrodiella albocinnamomea [J].

Chen, Zi-Ming ;

Wang, Shun-Lin .

NATURAL PRODUCT RESEARCH, 2015, 29 (21) :1985-1989

[3] Hypoglycemic effects of polysaccharides from corn silk (Maydis stigma) and their beneficial roles via regulating the PI3K/Akt signaling pathway in L6 skeletal muscle [J].

Guo, Qingwen ;

Chen, Zhongqin ;

Santhanam, Ramesh Kumar ;

Xu, Leilei ;

Gao, Xudong ;

Ma, Qiqi ;

Xue, Zihan ;

Chen, Haixia .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 121 :981-988

[4] In-vitro neuroprotective properties of the Maydis stigma extracts from four corn varieties [J].

Kan, Asuman ;

Orhan, Ilkay ;

Coksari, Gulay ;

Sener, Bilge .

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2012, 63 (01) :1-4

[5] A green and cost-effective approach for the production of gold nanoparticles using corn silk extract: A recoverable catalyst for Suzuki-Miyaura reaction and adsorbent for removing of dye pollutants [J].

Khodaei, Mohammad Mehdi ;

Dehghan, Mahsa .

POLYHEDRON, 2019, 162 :219-231

[6] RESOLUTION OF (+-)-ZEARALENONE . DETERMINATION OF ABSOLUTE CONFIGURATION OF NATURAL ENANTIOMORPH [J].

KUO, CH ;

TAUB, D ;

HOFFSOMM.RD ;

WENDLER, NL .

CHEMICAL COMMUNICATIONS, 1967, (15) :761-&

[7] ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk (Zea mays) [J].

Qi, Xiao-Li ;

Zhang, Ying-Ying ;

Zhao, Peng ;

Zhou, Le ;

Wang, Xiao-Bo ;

Huang, Xiao-Xiao ;

Lin, Bin ;

Song, Shao-Jiang .

JOURNAL OF NATURAL PRODUCTS, 2018, 81 (05) :1225-1234

[8] ISOLATION AND SYNTHESIS OF AN INSECT RESISTANCE FACTOR FROM CORN PLANTS [J].

SMISSMAN, EE ;

LAPIDUS, JB ;

BECK, SD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (17) :4697-4698

[9] Zeasesquiterpene A-E, new sesquiterpenes from the roots of Zea mays [J].

Wang, An-dong ;

Zhang, Yun-qiang ;

Li, Mei-chen ;

Wang, Xia ;

Lin, Bin ;

Liu, Jian-yu ;

Xu, Yong-nan .

FITOTERAPIA, 2018, 131 :15-22

[10] Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities [J].

Wang, Kai-Jin ;

Zhao, Jin-Liang .

BIOMEDICINE & PHARMACOTHERAPY, 2019, 110 :510-517