Metaboloepigenetic Regulation of Pluripotent Stem Cells

被引：45

作者：

Harvey, Alexandra J. ^{[1
,2
]}

Rathjen, Joy ^{[1
,2
,3
]}

Gardner, David K. ^{[1
,2
]}

机构：

[1] Stem Cells Australia, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Sch BioSci, Parkville, Vic 3010, Australia

[3] Univ Tasmania, Sch Med, Hobart, Tas 7000, Australia

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

关键词：

HYPOXIA-INDUCIBLE FACTORS; AMINO-ACID; DNA DEMETHYLATION; ENERGY-METABOLISM; OXYGEN-TENSION; ES CELLS; PREIMPLANTATION EMBRYO; FUNCTIONAL-PROPERTIES; DEVELOPMENTAL GENES; SIR2-ALPHA PROTEIN;

D O I：

10.1155/2016/1816525

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape. Epigenetic regulation is essential for the modulation of differentiation, being responsible for cell type specific gene expression patterns through the modification of DNA and histones, thereby establishing cell identity. Each cell type has its own idiosyncratic pattern regarding the use of specific metabolic pathways. Rather than simply being perceived as a means of generating ATP and building blocks for cell growth and division, cellular metabolism can directly influence cellular regulation and the epigenome. Consequently, the significance of nutrients and metabolites as regulators of differentiation is central to understanding how cells interact with their immediate environment. This review serves to integrate studies on pluripotent stem cell metabolism, and the regulation of DNA methylation and acetylation and identifies areas in which current knowledge is limited.

引用

页数：15

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