Clemmensen reduction of diosgenin and kryptogenin:: synthesis of [16,16,22,22,23,23-2H6]-(25R)-26-hydroxycholesterol

被引：13

作者：

Alessandrini, L ^{[1
]}

Ciuffreda, P ^{[1
]}

Santaniello, E ^{[1
]}

Terraneo, G ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Precliniche LITA Vialba, I-20157 Milan, Italy

来源：

STEROIDS | 2004年 / 69卷 / 13-14期

关键词：

deuterated isotopomers; 26-hydroxycholesterol; Clemmensen reduction; kryptogenin; diosgenin; cholesterol metabolism;

D O I：

10.1016/j.steroids.2004.09.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new experimental protocol has been established for the Clemmensen reduction of diosgenin and kryptogenin with the aim to prepare deuterated isotopomers of (25R)-26-hydroxycholesterol. Uncontrolled deuteration has been achieved from diosgenin, whereas [16,16,22,22,23,232 H-2(6)]-(25R)-26-hydroxycholesterol (1) can be synthesized from kryptogenin. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：789 / 794

页数：6

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