Vγ9Vδ2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection

被引：14

作者：

Martini, F

Paglia, MG

Montesano, C

Enders, PJ

Gentile, M

Pauza, CD

Gioia, C

Colizzi, V

Narciso, P

Pucillo, LP

Poccia, F

机构：

[1] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Clin Pathol Lab, I-00149 Rome, Italy

[2] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Clin Div 4, I-00149 Rome, Italy

[3] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, ICAERI, I-00149 Rome, Italy

[4] Univ Maryland, Inst Biotechnol, Inst Human Virol, Baltimore, MD 21021 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 05期

关键词：

D O I：

10.1128/IAI.71.5.2945-2949.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vgamma9Vdelta2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in Vgamma9Vdelta2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, Vgamma9Vdelta2 T cells were early activated but rapidly became anergic and finally loose Jgamma1.2 Vgamma9 complementarity-determining region 3 transcripts.

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页码：2945 / 2949

页数：5

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