Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits

被引：9

作者：

Calloi Palozi, Rhanany Alan ^{[1
]}

Guarnier, Lucas Pires ^{[1
]}

Moreira Romao, Paulo Vitor ^{[1
]}

Nocchi, Samara Requena ^{[2
]}

dos Santos, Carlos Calixto ^{[3
]}

Botelho Lourenco, Emerson Luiz ^{[3
]}

Silva, Denise Brentan ^{[2
]}

Gasparotto, Francielly Mourao ^{[1
]}

Gasparotto Junior, Arquimedes ^{[1
]}

机构：

[1] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Lab Eletrofisiol & Farmacol Cardiovasc LEFaC, Dourados, MS, Brazil

[2] Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutr FACFAN, Lab Prod Nat & Espectrometria Massas LaPNEM, Campo Grande, MS, Brazil

[3] Univ Paranaense, Lab Pesquisa Preclin Prod Nat, Umuarama, PR, Brazil

来源：

TOXICOLOGY REPORTS | 2019年 / 6卷

关键词：

Cardiovascular; Irwin test; Myrtaceae; Respiratory; Toxicology; MYRCIARIA-CAULIFLORA; ELLAGIC ACID; OXIDATIVE STRESS; JABOTICABA; EXTRACTS; CELLS; RAT; ANTIOXIDANT; METABOLITES; TOXICITY;

D O I：

10.1016/j.toxrep.2019.06.017

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Fruit peels of Plinia cauliflora (Mart) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study showed that EEPC did not cause any significant changes in respiratory, cardiovascular, or central nervous system function. These data provide scientific evidence of the effects of this species and important safety data for its clinical use.

引用

页码：616 / 624

页数：9