Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs

被引：67

作者：

Liu, Tse-Ying ^{[1
]}

Lin, Yi-Ling ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 04期

关键词：

Chitosan derivatives; pH-sensitive hydrogel; Cell compatibility; Controlled release; CARBOXYMETHYL-HEXANOYL CHITOSAN; N; O-CARBOXYMETHYL CHITOSAN; ADHESION; DELIVERY; BEHAVIOR; PROTEIN; CARRIER; ACETYLATION; DERIVATIVES; PREVENTION;

D O I：

10.1016/j.actbio.2009.10.010

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Carboxymethyl-hexanoyl chitosan (CHC) is an amphiphilic chitosan derivative with excellent swelling ability and water solubility under natural conditions. In this work, the influence of the degree of carboxymethyl and hexanoyl substitution on the pH-sensitive swelling behavior, drug release behavior, and antiadhesion behavior of CHC hydrogels (cross-linked with genipin) were studied. It was found that the pH sensitivity was more pronounced in CHC than in N,O-carboxymethyl chitosan because the hexanoyl group altered the state of water in CHC by inhibiting intermolecular hydrogen bonding. In addition, greater pH sensitivity was observed in samples bearing longer hydrophobic chains (carboxymethyl-palmityl chitosan). Interestingly, when used with ibuprofen (a poorly water-soluble therapeutic agent used here as a model drug), the bursting release of the drug was less prominent in the CHC samples having a high degree of carboxymethyl substitution. The CHC hydrogel also demonstrated good cell compatibility and its antiadhesive ability after grafting was altered by changes in the degree of hexanoyl substitution. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1423 / 1429

页数：7

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