A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn

被引：2

作者：

Hallouin, F ^{[1
]}

Goupille, C ^{[1
]}

Rocher, J ^{[1
]}

Le Pendu, J ^{[1
]}

机构：

[1] Inst Biol, INSERM, U419, F-44093 Nantes, France

来源：

GLYCOCONJUGATE JOURNAL | 1999年 / 16卷 / 11期

关键词：

vaccination; Sialyl-Tn antigen; rat model;

D O I：

10.1023/A:1007199124074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.

引用

页码：681 / 684

页数：4

共 10 条

[1] INTERACTION BETWEEN 2 CELLULAR SUBPOPULATIONS OF A RAT COLONIC-CARCINOMA WHEN INOCULATED TO THE SYNGENEIC HOST [J].