Structure-activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases

被引：8

作者：

Burakova, E. ^{[1
]}

Kovalev, N. ^{[1
]}

Zenkova, M. ^{[1
]}

Vlassov, V. ^{[1
]}

Silnikov, V. ^{[1
]}

机构：

[1] Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

来源：

BIOORGANIC CHEMISTRY | 2014年 / 57卷

关键词：

Artificial ribonucleases; Lipophilicity; Phosphodiester bond cleavage; RNA; RNA CLEAVAGE; CATALYSTS; COMPLEXES;

D O I：

10.1016/j.bioorg.2014.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we designed and synthesised new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octane ( DABCO) moieties with hydrophobic groups connected by different linkers. The structure and the RNA-cleavage activity relationships of this novel series of artificial ribonucleases (aRNases) were investigated. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：127 / 131

页数：5

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