Sphingosine Kinases: Emerging Structure-Function Insights

被引：60

作者：

Adams, David R. ^{[1
]}

Pyne, Susan ^{[2
]}

Pyne, Nigel J. ^{[2
]}

机构：

[1] Heriot Watt Univ, Inst Chem Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, 161 Cathedral St, Glasgow G4 0RE, OR, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 05期

关键词：

MAMMALIAN DIACYLGLYCEROL KINASES; PLASMA-MEMBRANE; DEPENDENT TRANSLOCATION; CELL-PROLIFERATION; CRYSTAL-STRUCTURE; ACTIVATION; BINDING; 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE; RECEPTOR;

D O I：

10.1016/j.tibs.2016.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SKI and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease.

引用

页码：395 / 409

页数：15

共 73 条

[1] Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase [J].

Alemany, R ;

Heringdorf, DMZ ;

van Koppen, CJ ;

Jakobs, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (07) :3994-3999

[2] Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site [J].

Bakali, H. M. Amin ;

Herman, Maria Dolores ;

Johnson, Kenneth A. ;

Kelly, Amelie A. ;

Wieslander, AKe ;

Hallberg, B. Martin ;

Nordlund, Par .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (27) :19644-19652

[3] Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A [J].

Barr, Renae K. ;

Lynn, Helen E. ;

Moretti, Paul A. B. ;

Khew-Goodall, Yeesim ;

Pitson, Stuart M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (50) :34994-35002

[4] Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors [J].

Blaho, Victoria A. ;

Hla, Timothy .

CHEMICAL REVIEWS, 2011, 111 (10) :6299-6320

[5] Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway [J].

Blaukat, A ;

Dikic, I .

BIOLOGICAL CHEMISTRY, 2001, 382 (01) :135-139

[6] Post-translational regulation of sphingosine kinases [J].

Chan, Huasheng ;

Pitson, Stuart M. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (01) :147-156

[7] Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate [J].

Cuvillier, O ;

Pirianov, G ;

Kleuser, B ;

Vanek, PG ;

Coso, OA ;

Gutkind, JS ;

Spiegel, S .

NATURE, 1996, 381 (6585) :800-803

[8] Sphingosine kinase 1 is an intracellular effector of phosphatidic acid [J].

Delon, C ;

Manifava, M ;

Wood, E ;

Thompson, D ;

Krugmann, S ;

Pyne, S ;

Ktistakis, NT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) :44763-44774

[9] Structural Basis of Lipid Binding for the Membrane-embedded Tetraacyldisaccharide-1-phosphate 4′-Kinase LpxK [J].

Emptage, Ryan P. ;

Tonthat, Nam K. ;

York, John D. ;

Schumacher, Maria A. ;

Zhou, Pei .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (35) :24059-24068

[10] Identification of Novel Integrin Binding Partners for Calcium and Integrin Binding Protein 1 (CIB1): Structural and Thermodynamic Basis of CIB1 Promiscuity [J].

Freeman, Thomas C., Jr. ;

Black, Justin L. ;

Bray, Holly G. ;

Dagliyan, Onur ;

Wu, Yi I. ;

Tripathy, Ashutosh ;

Dokholyan, Nikolay V. ;

Leisner, Tina M. ;

Parise, Leslie V. .

BIOCHEMISTRY, 2013, 52 (40) :7082-7090

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