Chromosomal aberrations induced by imipramine and desipramine in mouse

被引：9

作者：

Madrigal-Bujaidar, E. ^{[1
]}

Cardenas Garcia, Y. ^{[2
]}

Alvarez-Gonzalez, I.

机构：

[1] IPN, Escuela Nacl Ciencias Biol, Genet Lab, Unidad Profes A Lopez Mateos, Mexico City 07738, DF, Mexico

[2] IPN, Escuela Super Med, Mexico City 07738, DF, Mexico

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2010年 / 29卷 / 04期

关键词：

imipramine; desipramine; chromosomes; mouse; TRICYCLIC ANTIDEPRESSANTS; GENOTOXICITY EVALUATION; CANCER; RISK; PHARMACOKINETICS; AMITRIPTYLINE; TRANSPORTER; INSTABILITY; TOXICITY; DRUGS;

D O I：

10.1177/0960327110361751

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Imipramine (IMI) and desipramine (DES) are two drugs widely used for the treatment of depression as well as for other diseases. In the present study, we determined their capacity to induce chromosomal aberrations in mouse bone marrow cells. Three doses of each compound were tested and their results were compared with the frequency of chromosomal aberrations obtained in a control group as well as with a group treated with cyclophosphamide. Our results showed a significant increase in chromosome damage with the doses tested for each compound: 7, 20, and 60 mg/kg in the case of IMI, and 2, 20, and 60 mg/kg as regards DES. This last drug induced stronger chromosomal damage than IMI. Our results agree with previous studies regarding the induction of micronuclei and sister chromatid exchanges by the drugs in mouse and suggest caution with respect to their use in long-term treatments.

引用

页码：297 / 302

页数：6

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