The Eating Disorders Genetics Initiative (EDGI): study protocol

被引：30

作者：

Bulik, Cynthia M. ^{[1
,2
,3
]}

Thornton, Laura M. ^{[1
]}

Parker, Richard ^{[4
]}

Kennedy, Hannah ^{[5
]}

Baker, Jessica H. ^{[1
]}

MacDermod, Casey ^{[1
]}

Guintivano, Jerry ^{[1
]}

Cleland, Lana ^{[5
]}

Miller, Allison L. ^{[6
]}

Harper, Lauren ^{[1
]}

Larsen, Janne T. ^{[7
,8
]}

Yilmaz, Zeynep ^{[7
,8
]}

Grove, Jakob ^{[8
,9
,10
,11
,12
]}

Sullivan, Patrick F. ^{[1
,2
,13
]}

Petersen, Liselotte, V ^{[7
,8
]}

Jordan, Jennifer ^{[5
]}

Kennedy, Martin A. ^{[6
]}

Martin, Nicholas G. ^{[4
]}

机构：

[1] Univ N Carolina, Dept Psychiat, CB 7160,101 Manning Dr, Chapel Hill, NC 27599 USA

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, SE-17177 Stockholm, Sweden

[3] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA

[4] Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Locked Bag 2000, Herston, Qld 4029, Australia

[5] Univ Otago, Dept Psychol Med, Christchurch, New Zealand

[6] Univ Otago, Dept Pathol & Biomed Sci, Christchurch, New Zealand

[7] Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark

[8] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus, Denmark

[9] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[10] iSEQ, CGPM, Aarhus, Denmark

[11] iSEQ, Ctr Integrat Sequencing, Aarhus, Denmark

[12] Aarhus Univ, Bioinformat Res Ctr, Aarhus, Denmark

[13] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

来源：

BMC PSYCHIATRY | 2021年 / 21卷 / 01期

关键词：

Anorexia nervosa; Bulimia nervosa; Binge-eating disorder; Eating disorders; Genome-wide association; Psychiatric genetics; Psychiatric genomics consortium; Social media; ASSOCIATION; VALIDATION; HOMOZYGOSITY; METAANALYSIS; COMPONENTS; RISK; LOCI; RUNS;

D O I：

10.1186/s12888-021-03212-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. Methods A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). Discussion EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.

引用

页数：9

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