Bronsted Acid Catalyzed Asymmetric Aldol Reaction: A Complementary Approach to Enamine Catalysis

被引：79

作者：

Pousse, Guillaume ^{[1
]}

Le Cavelier, Fabien ^{[1
]}

Humphreys, Luke ^{[2
]}

Rouden, Jacques ^{[1
]}

Blanchert, Jerome ^{[1
]}

机构：

[1] Univ Caen Basse Normandie, ENSICAEN, Lab Chim Mol & Thioorgan, CNRS, F-14050 Caen, France

[2] GlaxoSmithKline, Synthet Chem, Chem Dev, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 16期

关键词：

MUKAIYAMA-ALDOL; ENANTIOSELECTIVE SYNTHESIS; DIELS-ALDER; ALDEHYDES; CYCLIZATION; ACTIVATION;

D O I：

10.1021/ol101176j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A syn-enantioselective aldol reaction has been developed using Bronsted acid catalysis based on H-8-BINOL-derived phosphoric acids. This method affords an efficient synthesis of various beta-hydroxy ketones, some of which could not be synthesized using enamine organocatalysis.

引用

页码：3582 / 3585

页数：4

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