The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

被引：242

作者：

Petrosino, Stefania ^{[1
]}

Di Marzo, Vincenzo ^{[1
]}

机构：

[1] CNR, Endocannabinoid Res Grp, ICB, Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 11期

关键词：

FATTY-ACID AMIDE; ACTIVATED-RECEPTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; ENDOCANNABINOID-RELATED MOLECULES; ALLERGIC CONTACT-DERMATITIS; CANNABINOID CB2 RECEPTOR; N-PALMITOYL-ETHANOLAMINE; NEUROPATHIC PAIN; CONCISE GUIDE; PPAR-ALPHA;

D O I：

10.1111/bph.13580

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this compound is naturally produced in many plant and animal food sources, as well as in cells and tissues of mammals, and endowed with important neuroprotective, anti-inflammatory and analgesic actions. Several efforts have been made to identify the molecular mechanism of action of PEA and explain its multiple effects both in the central and the peripheral nervous system. Here, we provide an overview of the pharmacology, efficacy and safety of PEA in neurodegenerative disorders, pain perception and inflammatory diseases. The current knowledge of new formulations of PEA with smaller particle size (i.e. micronized and ultra-micronized) when given alone or in combination with antioxidant flavonoids (i.e. luteolin) and stilbenes (i.e. polydatin) is also reviewed.

引用

页码：1349 / 1365

页数：17

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