A new polymer-supported reagent for the synthesis of β-lactams in solution

被引：32
作者：
Donati, D
Morelli, C
Porcheddu, A
Taddei, M
机构：
[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy
[2] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy
[3] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 26期
关键词：
D O I：
10.1021/jo048400i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.
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收藏
页码：9316 / 9318
页数：3
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