Should expectant mothers be vaccinated against flu? A safety review

被引：15

作者：

Loubet, Paul ^{[1
,2
]}

Kerneis, Solen ^{[1
,2
,3
]}

Anselem, Olivia ^{[4
,5
,6
,7
]}

Tsatsaris, Vassilis ^{[3
,4
,5
,6
,7
]}

Goffinet, Francois ^{[3
,4
,5
,6
,7
,8
]}

Launay, Odile ^{[1
,2
,3
,9
]}

机构：

[1] CIC Cochin Pasteur, INSERM, Paris, France

[2] Descartes Univ, Cochin Hosp, Paris AP HP, Dept Internal Med,Infect Dis Ward, Paris, France

[3] Sorbonne Paris Cite Univ, Paris, France

[4] Maternite Port Royal, Grp Hosp Cochin Broca Hotel Dieu, AP HP, Paris, France

[5] Descartes Univ, Cochin Broca Hotel Dieu Hosp, Paris AP HP, Dept Obstet & Gynecol, Paris, France

[6] PremUp Fdn Sci Cooperat Connect Pregnancy & Prema, Paris, France

[7] DHU Risk Pregnancy, Paris, France

[8] Epidemiol Res Unit Perinatal Hlth & Womens & Chil, INSERM, U953, Paris, France

[9] Grp Hosp Cochin St Vincent de Paul, F-75679 Paris 14, France

来源：

EXPERT OPINION ON DRUG SAFETY | 2014年 / 13卷 / 12期

关键词：

adjuvant; effectiveness; fetus; newborn; pandemic; 2009; A/H1N1; influenza; pregnancy; safety; seasonal influenza; vaccination; vaccine; GUILLAIN-BARRE-SYNDROME; INACTIVATED INFLUENZA VACCINE; PLACEBO-CONTROLLED TRIAL; GESTATIONAL-AGE BIRTH; PREGNANT-WOMEN; H1N1; INFLUENZA; VIRUS-INFECTION; PROSPECTIVE COHORT; NEONATAL OUTCOMES; OBSTETRIC EVENTS;

D O I：

10.1517/14740338.2014.977252

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Pregnant women have a higher risk of serious complications from influenza than non-pregnant women of reproductive age. This increased risk has been noted both during pandemic and inter-pandemic influenza seasons. However, although vaccination against flu is recommended at any trimesters by international and national policies, vaccine coverage remains low in pregnant women, possibly due to patient and healthcare providers' concern about the safety of the vaccine. Areas covered: This review addresses the effectiveness and safety of seasonal and adjuvanted and non-adjuvanted pandemic 2009 A/H1N1 influenza vaccine. Expert opinion: Available data suggest no evidence of an increased risk for any adverse event for both mothers and fetuses after vaccination against flu during pregnancy. These results are important when considering the potential of maternal immunization against flu as a public health intervention to protect both the mother and her infant against serious infectious disease.

引用

页码：1709 / 1720

页数：12

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