Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products

被引：12

作者：

Hino, Christopher ^{[1
]}

Pham, Bryan ^{[1
]}

Park, Daniel ^{[2
]}

Yang, Chieh ^{[3
]}

Nguyen, Michael H. K. ^{[4
]}

Kaur, Simmer ^{[4
]}

Reeves, Mark E. ^{[4
]}

Xu, Yi ^{[4
]}

Nishino, Kevin ^{[1
]}

Pu, Lu ^{[1
]}

Kwon, Sue Min ^{[1
]}

Zhong, Jiang F. ^{[5
]}

Zhang, Ke K. ^{[6
,7
]}

Xie, Linglin ^{[6
,7
]}

Chong, Esther G. ^{[4
]}

Chen, Chien-Shing ^{[4
]}

Nguyen, Vinh ^{[8
]}

Castillo, Dan Ran ^{[4
]}

Cao, Huynh ^{[4
]}

机构：

[1] Loma Linda Univ, Sch Med, Dept Internal Med, Loma Linda, CA 92354 USA

[2] Univ Calif San Francisco, Sch Med, Dept Internal Med, Fresno, CA 93701 USA

[3] Univ Calif Riverside, Sch Med, Dept Internal Med, Riverside, CA 92521 USA

[4] Loma Linda Univ, Sch Med, Dept Oncol Hematol, Loma Linda, CA 92354 USA

[5] Loma Linda Univ, Dept Basic Sci, Loma Linda, CA 92354 USA

[6] Texas A&M Univ, Dept Nutr, College Stn, TX 77030 USA

[7] Texas A&M Univ, Coll Med, Ctr Epigenet & Dis Prevent, Inst Biosci & Technol, Houston, TX 77030 USA

[8] Univ Calif Riverside, Dept Biol, Riverside, CA 92521 USA

来源：

BIOMEDICINES | 2022年 / 10卷 / 06期

关键词：

acute myeloid leukemia; tumor microenvironment; immunotherapy; natural products; REGULATORY T-CELLS; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; INFILTRATING LYMPHOCYTES; VITAMIN-C; NK CELLS; ADOPTIVE IMMUNOTHERAPY; ANTILEUKEMIC ACTIVITY; SIGNALING PATHWAYS; SUPPRESSOR-CELLS;

D O I：

10.3390/biomedicines10061410

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor microenvironment (TME) plays an essential role in the development, proliferation, and survival of leukemic blasts in acute myeloid leukemia (AML). Within the bone marrow and peripheral blood, various phenotypically and functionally altered cells in the TME provide critical signals to suppress the anti-tumor immune response, allowing tumor cells to evade elimination. Thus, unraveling the complex interplay between AML and its microenvironment may have important clinical implications and are essential to directing the development of novel targeted therapies. This review summarizes recent advancements in our understanding of the AML TME and its ramifications on current immunotherapeutic strategies. We further review the role of natural products in modulating the TME to enhance response to immunotherapy.

引用

页数：23

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