Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies

被引：87

作者：

Chinnery, PF

Taylor, GA

Howell, N

Andrews, RM

Morris, CM

Taylor, RW

McKeith, IG

Perry, RH

Edwardson, JA

Turnbull, DM

机构：

[1] Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Newcastle Gen Hosp, Inst Hlth Elderly, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[3] Univ Texas, Med Branch, Dept Radiat Oncol, Galveston, TX 77550 USA

来源：

NEUROLOGY | 2000年 / 55卷 / 02期

关键词：

D O I：

10.1212/WNL.55.2.302

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup Il was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.

引用

页码：302 / 304

页数：3

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