In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone

被引：230
|
作者：
Jukic, Mila
Politeo, Olivera
Maksimovic, Milka
Milos, Mia
Milos, Mladen
机构：
[1] Univ Split, Dept Biochem, Fac Chem & Technol, Split 21000, Croatia
[2] Univ Sarajevo, Dept Organ Chem, Fac Sci, Sarajevo 71000, Bosnia & Herceg
[3] Univ Geneva, Dept Chem Phys, Fac Sci, CH-1204 Geneva, Switzerland
来源：
PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 03期
关键词：
Thymus vulgaris; acetylcholinesterase; thymol; carvacrol; thymoquinone; thymohydroquinone;
D O I：
10.1002/ptr.2063
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of this study was to examine in vitro the inhibitory activity exerted by the main constituents of essential oil obtained from the aromatic plant Thymus vulgaris L. on acetylcholinesterase (AChE). The total essential oil and selected compounds, specifically linalool and thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone, were tested for ACNE inhibition. Thymohydroquinone exhibited the strongest ACNE inhibitory effect over the range of concentrations. The ACNE inhibitory potential decreased in the following order: thymohydroquinone > carvacrol > thymoquinone > essential oil > thymol > linalool. It is interesting that the ACNE inhibitory effect exerted by carvacrol was 10 times stronger than that exerted by its isomer thymol, although thymol and carvacrol have a very similar structure. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：259 / 261
页数：3
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